Which of the following is an indicator of drug tolerance?
a. A decrease in the effectiveness of a drug resulting from repeated administrations.
b. A decrease in the potency of a drug resulting from repeated administrations.
c. The necessity to increase the dose of a drug in order to achieve the same effect after repeated administrations.
d. A shift to the right in a drug’s dose–response curve resulting from repeated administrations.
e. All of the above are indicators of drug tolerance.
Answer: E
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