Which of the following diseases is immune mediated and characterized by separation of the epidermis from the epidermal-dermal basement membrane?

A. pemphigus vulgaris
B. pemphigus foliaceus
C. bullous pemphigoid
D. epidermolysis bullosa simplex
E. junctional epidermolysis bullosa


C
Bullous pemphigoid is caused by antibodies that disrupt the contact between the basal layers of the epidermis and the basement membrane, leading to formation of subepidermal bullae. In pemphigus, the antibodies bind to cell surface attachment complexes (desmosomal components) and cause intraepidermal bullae. Epidermolysis bullosa, a disease that occurs in several variant forms, is an inborn defect and the bullae it causes are not of immune origin.

Health & Biomechanics

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