A patient being treated with paroxetine (Paxil) 50 mg/day orally for depression reports to the clinic nurse, "I took a few extra tablets earlier in the day and now I feel bad." Which assessments are most critical? Select all that apply
a. Vital signs
b. Urinary frequency
c. Increased suicidal ideation
d. Presence of abdominal pain and diarrhea
e. Hyperactivity or feelings of restlessness
ANS: A, D, E
The patient is taking the maximum dose of this SSRI and has ingested an additional unknown amount of the drug. Central serotonin syndrome must be considered. Symptoms include abdominal pain, diarrhea, tachycardia, elevated blood pressure, hyperpyrexia, increased motor activity, and muscle spasms. Central serotonin syndrome may progress to a full medical emergency if not treated early. Although assessing for suicidal ideation is never inappropriate, in this situation physiologic symptoms should be the initial focus. The patient may have urinary retention, but frequency would not be expected.
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