What is the action of MAOIs on neurotransmitters?
a. Blocking their reuptake
b. Increasing their production
c. Blocking their destruction
d. Increasing their reuptake
ANS: C
MAOIs act by blocking the metabolic destruction of epinephrine, norepinephrine, dopamine, and serotonin neurotransmitters by the enzyme monoamine oxidase in the presynaptic neurons of the brain. They prevent the degradation of these central nervous system (CNS) neurotransmitters so that their concentration is increased. MAOIs do not block or increase the reuptake of neurotransmitters. MAOIs do not increase production of neurotransmitters.
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