Angiotensin-converting enzyme (ACE) inhibitor drugs prevent ACE from breaking down which substances, resulting in some of the serious adverse effects of the ACE inhibitors?
1. Aldosterone
2. Bradykinin
3. Renin
4. RAAS
Correct Answer: 2
Rationale 1: ACE does not break down aldosterone.
Rationale 2: ACE, with several other enzymes, breaks down bradykinin, and if this accumulates, it can cause cough and angioedema.
Rationale 3: ACE does not break down renin.
Rationale 4: ACE is part of the RAAS system; it does not break it down.
Global Rationale: ACE, with several other enzymes, breaks down bradykinin, and if this accumulates, it can cause cough and angioedema. ACE does not break down aldosterone or renin. ACE is part of the RAAS system; it does not break it down.
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