When explaining the pathophysiology of Parkinson disease to a client, the nurse would explain that it is a degenerative disorder of the nervous system caused by the death of neurons that produce which substance?
1. Acetylcholine
2. Serotonin
3. Norepinephrine
4. Dopamine
Correct Answer: 4
Rationale 1: Parkinson disease is not caused by the death of neurons that produce acetylcholine.
Rationale 2: Parkinson disease is not caused by the death of neurons that produce serotonin.
Rationale 3: Parkinson disease is not caused by the death of neurons that produce norepinephrine.
Rationale 4: Symptoms of Parkinson disease develop due to the destruction of the dopamine-producing neurons located in the substantia nigra. These neurons supply dopamine to the corpus striatum, the region of the brain that controls unconscious muscle movement.
Global Rationale: Symptoms of Parkinson disease develop due to the destruction of the dopamine-producing neurons located in the substantia nigra. These neurons supply dopamine to the corpus striatum, the region of the brain that controls unconscious muscle movement. Parkinson disease is not caused by the death of neurons that produce acetylcholine, serotonin, or norepinephrine.
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