A nurse is preparing to administer a second infusion of trastuzumab (Herceptin) to a patient who has breast cancer. The patient tells the nurse that she experienced chills, fever, pain, and nausea after her first infusion. What will the nurse do?
a. Contact the provider to request a CBC to assess for neutropenia.
b. Ensure that oxygen and respiratory support measures are readily available.
c. Reassure the patient that these symptoms will diminish with each infusion.
d. Request an order for an electrocardiogram.
ANS: C
Patients taking trastuzumab may experience a flu-like syndrome with their first infusion that will diminish with subsequent infusions. Neutropenia is not a concern with this drug. Hypersensitivity reactions may occur, but the patient's symptoms are not characteristic of this. Cardiotoxicity may occur, but the symptoms are not characteristic of this.
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