Which of the following is true regarding malignant cells in serous fluids?
a. All clumps of large cells should be considered malignant.
b. Malignant cells in serous fluids are rarely seen.
c. Malignant cells categorize the fluid as a transudate.
d. Care must be taken to distinguish malignant cells from clumps of mesothelial cells.
ANS: D
Both malignant and mesothelial cells can be found in clumps in serous fluids. Mesothelial cells are normal lining cells of body cavities that are shed into these cavities; they are a normal finding in serous fluids. They can be confused with malignant cells. However, when mesothelial cells appear in clumps (a frequent occurrence), usually windows are noted between the cells. This is not true of malignant cells that are also commonly found in clumps.
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