The nurse is researching a drug that has a median effective dose (ED50) of 5 mg and a median lethal dose (LD50) of 20 mg. Which therapeutic index (TI) calculated by the nurse is correct?
1. 5
2. 4
3. 1
4. 10
Correct Answer: 2
Rationale 1: The TI is calculated by dividing the median LD by the median ED. Twenty divided by 5 does not equal 5.
Rationale 2: The TI is calculated by dividing the median LD by the median ED. Twenty divided by 5 equals 4.
Rationale 3: The TI is calculated by dividing the median LD by the median ED. Twenty divided by 5 does not equal 1.
Rationale 4: The TI is calculated by dividing the median LD by the median ED. Twenty divided by 5 does not equal 10.
Global Rationale: The TI is calculated by dividing the median LD by the median ED. Twenty divided by 5 equals 4.
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