What is the mechanism of action that differentiates opioid agonists from opioid agonist-antagonists?
1. Opioid agonists block two receptors; opioid agonist-antagonists have no effect on any receptors.
2. Opioid agonists activate two receptors; opioid agonist-antagonists occupy only one receptor.
3. Opioid agonists activate one receptor; opioid agonist-antagonists activate both receptors.
4. Opioid agonists block one receptor; opioid agonist-antagonists block both receptors.
Correct Answer: 2
Rationale 1: Opioid agonists do not block receptors. Opioid agonist-antagonists do have effects on the receptors, activating one and blocking or having no effect on the other.
Rationale 2: Opioid agonists activate both mu and kappa receptors, and opioid agonist-antagonists occupy only one receptor and block the other.
Rationale 3: Opioid agonists activate two receptors, and opioid agonist-antagonists activate only one receptor.
Rationale 4: Opioid agonists do not block receptors; opioid agonist-antagonists block only one receptor or have no effect on it.
Global Rationale: Opioid agonists activate both mu and kappa receptors, and opioid agonist-antagonists occupy only one receptor and block the other. Opioid agonists do not block receptors. Opioid agonist-antagonists do have effects on the receptors, activating one and blocking or having no effect on the other. Opioid agonists activate two receptors, and opioid agonist-antagonists activate only one receptor. Opioid agonists do not block receptors; opioid agonist-antagonists block only one receptor or have no effect on it.
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