A female patient presented to her primary care physician with classic signs and symptoms of Cushing syndrome. Upon testing, it was discovered that the patient had vaginal small cell carcinoma
How can the health care providers explain her Cushing syndrome signs and symptoms to this patient?
A)
"Your tumor in your vagina is secreting a hormone called adrenocorticotropic hormone (ACTH), which is responsible for these signs and symptoms."
B)
"We are going to have to run some more tests. We think you might have a problem with your pituitary gland."
C)
"There is no connection between the Cushing syndrome and the vaginal carcinoma. You have two very distinct problems occurring at the same time."
D)
"We need to check your thyroid. Your Cushing syndrome may be caused by hypofunction of this gland."
Ans:
A
Feedback:
Hyperfunction is usually associated with excessive hormone production. This can result from excessive stimulation and hyperplasia of the endocrine gland or from a hormone-producing tumor. A clinical example of this phenomenon is evidenced by the case of a woman with vaginal small cell carcinoma who also presented with Cushing syndrome. After testing, it was determined that the tumor is secreting ACTH. In this situation, the cause is not related to a pituitary problem. There is a connection between Cushing syndrome and the carcinoma. The thyroid gland is not responsible for Cushing syndrome.
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