A nurse is discussing the mechanism of action of spironolactone (Aldactone) with a group of nurses
The nurse states that spironolactone has been demonstrated to prolong survival as well as improve heart failure symptoms by which of the following actions?
a. Decreasing the excretion of sodium
b. Blocking receptors for aldosterone
c. Redistributing edema
d. Increasing the excretion of potassium
ANS: B
Spironolactone (Aldactone) blocks the action of aldosterone in the distal nephron and benefits patients with severe heart failure. Aldosterone acts to promote sodium uptake in exchange for potassium secretion; it therefore increases the excretion of sodium, promoting diuresis.
Spironolactone increases, rather than decreases, the excretion of sodium.
Spironolactone does not redistribute edema; rather, it is used to help reduce edema.
Spironolactone spares potassium removal rather than increasing its excretion.
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