A client with prostate cancer is being treated with leuprolide (Lupron). The nurse would counsel the client regarding which side effect?
1. Increased risk of infection
2. Decreased libido and hair loss
3. Nausea with possible vomiting
4. Increased risk of bleeding
Correct Answer: 2
Rationale 1: Neutropenia, or an abnormally low neutrophil count, is not an adverse effect.
Rationale 2: Leuprolide (Lupron) is a gonadotropin-releasing hormone agonist that reduces the levels of circulating testosterone. Therefore, it is useful to treat prostatic tumors that respond to testosterone stimulation. The main side effect of leuprolide (Lupron) therapy is drug-induced hypogonadism, resulting in decreased libido.
Rationale 3: Gastrointestinal disturbances are not associated with this drug treatment.
Rationale 4: Disturbances in clotting factors are not an adverse effect.
Global Rationale: Leuprolide (Lupron) is a gonadotropin-releasing hormone agonist that reduces the levels of circulating testosterone. Therefore, it is useful to treat prostatic tumors that respond to testosterone stimulation. The main side effect of leuprolide (Lupron) therapy is drug-induced hypogonadism, resulting in decreased libido.
Neutropenia, GI disturbances, and clotting abnormalities are not expected problems with this drug.
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