A client is prescribed an alpha1 antagonist for blood pressure control. When instructing the client, the nurse will include that this medication performs which action?
Standard Text: Select all that apply.
1. Blocks alpha1 receptors on arterial smooth muscle
2. Dilates veins
3. Blocks alpha2 receptors on arterial smooth muscle
4. Reduces the heart rate
5. Decrease the force of myocardial contraction
Correct Answer: 1,2
Rationale 1: Alpha1 antagonists block alpha1 receptors on arterial smooth muscle, which directly lowers blood pressure.
Rationale 2: Alpha1 antagonists dilate veins, which indirectly lowers the blood pressure by decreasing venous return to the heart.
Rationale 3: Although a few agents selectively block alpha2-adrenergic receptors, they are used for research purposes and have no clinical application.
Rationale 4: Beta blockers reduce the heart rate.
Rationale 5: Beta blockers reduce the force of myocardial contraction.
Global Rationale: Alpha1 antagonists block alpha1 receptors on arterial smooth muscle, which directly lowers blood pressure and they dilate veins, which indirectly lowers the blood pressure by decreasing venous return to the heart. Although a few agents selectively block alpha2-adrenergic receptors, they are used for research purposes and have no clinical application. Beta blockers reduce the heart rate and the force of myocardial contractions.
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