Which physiologic difference affects the absorption of oral medications administered to a 3-month-old infant?
a. More rapid peristaltic activity
b. More acidic gastric secretions
c. Usually more rapid gastric emptying
d. Variable pancreatic enzyme activity
D
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A Infants up to 8 months of age tend to have prolonged motility. The longer the
intestinal transit time, the more medication is absorbed.
B The gastric secretions of infants are less acidic than in older children or adults.
C Gastric emptying is usually slower in infants.
D Pancreatic enzyme activity is variable in infants for the first 3 months of life as
the gastrointestinal system matures. Medications that require specific enzymes
for dissolution and absorption might not be digested to a form suitable for
intestinal action.
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