Bone growth occurs at the metaphysis in a series of steps. Choose the number sequence that correctly orders the steps listed below.
(1) Minerals are deposited in the matrix between columns of lacunae.
(2) Chondrocytes multiply and arrange themselves into longitudinal columns of flattened lacunae.
(3) A region of spongy bone is produced.
(4) Chondrocytes enlarge (hypertrophy) and walls between the lacunae become thin.
(5) Chondrocytes die, walls between lacunae disintegrate, and osteoblasts deposit matrix.
A. 1, 2, 3, 4, 5
B. 2, 5, 1, 3, 4
C. 2, 1, 4, 5, 3
D. 4, 2, 5, 1, 3
E. 2, 4, 1, 5, 3
E. 2, 4, 1, 5, 3
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Fill in the blank(s) with the appropriate word(s).