A client asks, "Why do I have clogged arteries but my neighbor has higher 'bad cholesterol' levels and yet he is just fine?" The health care provider bases the reply on which of the following physiological principles about lipoprotein?
A) "Your neighbor probably has higher amounts of good cholesterol (HDL) as well."
B) "You more than likely have small, dense type of 'bad cholesterol' (LDL)."
C) "Your neighbor has larger 'bad cholesterol' particles that can move into blood vessels but park in joints/tendons."
D) "You must have a genetic predisposition to having clogged arteries."
Ans: B
Feedback:
There are different types of LDL, and some people with markedly elevated LDL do not develop atherosclerotic vascular disease, whereas other people with only modest elevations in LDL develop severe disease. Small, dense LDL is more toxic or atherogenic to the endothelium than large, buoyant LDL. It is more likely to enter the vessel wall, become oxidized, and trigger the atherosclerotic process.
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