Which of the following features of transcription initiation is least likely to contribute to the process of "abortive initiation"?

A. Early in initiation, the RNA exit channel of RNA polymerase is blocked by the polymerase itself.
B. Early in initiation, the RNA exit channel of RNA polymerase is blocked by the sigma factor.
C. The transition between the closed and open complex is energetically costly.
D. RNA is synthesized de novo, requiring no primer.
E. Early in initiation, the processivity of RNA polymerase is low.


C

Biology & Microbiology

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