The patient tells the nurse that he is on many medications, and questions how they all get to the right places. What is the best response by the nurse?
1. "It depends on how much protein you have in your body."
2. "It depends on the health of your kidneys."
3. "It depends on whether they are fat based or water based."
4. "It depends on the amount of blood flow to your body tissues."
5. "It depends on the health of your liver."
Correct Answer: 1,3,4
Rationale: Distribution of drugs depends on the amount of blood flow to body tissues, the lipid solubility of the drug, and protein binding. The health of the liver refers to metabolism, not distribution. The health of the kidneys refers to excretion, not distribution.
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