The student nurse asks the nursing instructor why drug plateaus occur with medications. What is (are) the best response(s) by the nursing instructor?
1. "It could be that all of the receptors for the drug are occupied."
2. "It may mean that the drug has brought 100% relief to the patient."
3. "It means that the patient has developed resistance and needs another drug."
4. "It probably means that the drug is losing efficacy."
5. "It means that the patient needs a higher dose of the drug."
Correct Answer: 1,2
Rationale: Drug plateaus occur with medications because all the receptors for the drug are occupied; the drug has brought 100% relief to the patient. A drug plateau is not related to efficacy of the drug. When a drug has reached its plateau, giving additional amounts will not result in an increased therapeutic effect.
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