Describe in detail how the renin angiotensin negative feedback loop helps regulate blood pressure and glomerular filtration rate in response to dehydration

What will be an ideal response


Dehydration causes a decrease in blood volume and pressure, which then decreases glomerular filtration rate (GFR). The juxtaglomerular( JG) cells of the juxtaglomerular apparatus sense decreased stretch and macula densa cells sense decreased water. The JG cells secrete renin, which converts angiotensinogen in blood to angiotensin I. The latter is converted to angiotensin II by angiotensin converting enzymes in the lungs. Angiotensin II causes constriction of efferent arterioles, increased thirst, greater ADH secretion from the posterior pituitary, and increased secretion of aldosterone from the adrenal cortex. Blood volume is increased, which increases venous return, stroke volume, cardiac output, and blood pressure. GFR is also increased.

Anatomy & Physiology

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Indicate whether the statement is true or false

Anatomy & Physiology

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What will be an ideal response?

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Which is NOT true about a binding site on a protein?

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Anatomy & Physiology

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Anatomy & Physiology