Consider a protein that is targeted to be an integral membrane protein on the surface of a cell. It has a specific functional domain (domain X) facing the external environment of the cell. How will this protein be oriented in the E.R.?
A) It will be embedded in the E.R. membrane with domain X facing the cytoplasm of the cell.
B) It will be embedded in the E.R. membrane with domain X facing the lumen of the E.R.
C) It will be completely within the E.R. lumen, not embedded in the membrane.
D) It will be outside the E.R. as a peripheral membrane protein.
Ans: B) It will be embedded in the E.R. membrane with domain X facing the lumen of the E.R.
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