Which drugs may reach toxic blood levels if administered with macrolide antibiotics? (Select all that apply.)
a. Benzodiazepines
b. Digoxin
c. NSAIDs
d. HMG CoA reductase inhibitors
e. Diuretics
f. Theophylline
ANS: A, B, D, F
Macrolide antibiotics may inhibit the metabolism of benzodiazepines, digoxin, HMG CoA reductase inhibitors, and theophylline, causing accumulation and potential toxicity. NSAIDs and diuretics are not inhibited by macrolide antibiotics.
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