Infants have decreased plasma protein-binding sites because of decreased plasma protein and albumin levels. With drugs that are highly protein bound, how should the drug dose for infants be different from that for adults?
a. It should be higher.
b. It should be lower.
c. It should be the same.
d. It varies by client.
ANS: B
With fewer protein-binding sites, there is more active drug available. This requires a reduction in the dose for infants.
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