The emergency room nurse is teaching a class for newly hired graduate nurses on the different types of local anesthetic agents. How would the nurse differentiate lidocaine and procaine as a local anesthetic agent?
A) Lidocaine is an amide that is broken down slowly and this can lead to toxicity.
B) Lidocaine is an ester that cannot become toxic in the system because of rapid metabolism.
C) Procaine is an amide that is broken down immediately in the tissues.
D) Procaine is metabolized by the liver with risk of toxicity and is classified as an ester.
A
Feedback:
The ester local anesthetics are broken down immediately in the plasma by enzymes known as plasma esterases. The amide local anesthetics are metabolized more slowly in the liver. Serum levels of these drugs can become elevated and lead to toxicity. Lidocaine is an amide and procaine is an ester.
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