A client taking gemfibrozil (Lopid) and rosuvastatin (Crestor) reports muscle and joint pain. The nurse's response is based on an interpretation that this complaint might indicate which manifestation?
1. Hepatic injury
2. Peripheral neuropathy
3. Myopathy
4. An inflammatory response
Correct Answer: 3
Rationale 1: Hepatic injury is a risk associated with these drugs, but the symptom pattern does not indicate damage to the liver.
Rationale 2: Joint pain is not a manifestation of peripheral nerve damage.
Rationale 3: The risk of myopathy is increased in clients taking both a fibrate and a statin drug for hyperlipidemia.
Rationale 4: The mechanism by which statin and fibrate drugs produce myopathy is unknown.
Global Rationale: The risk of myopathy is increased in clients taking both a fibrate and a statin drug for hyperlipidemia. Hepatic injury is a risk associated with these drugs, but the symptom pattern does not indicate damage to the liver. Joint pain is not a manifestation of peripheral nerve damage. The mechanism by which statin and fibrate drugs produce myopathy is unknown.
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