A client has been prescribed clopidogrel (Plavix). The nurse instructs the client that which types of drugs can increase the risk for bleeding?(Select all that apply.)
1. Anticoagulants
2. Protein pump inhibitors
3. Thrombolytic agents
4. Antibiotics
5. Aspirin
1, 2, 3, 5
Rationale 1: Use with anticoagulants will increase the risk of bleeding.
Rationale 2: Use of protein pump inhibitors will increase the risk of bleeding.
Rationale 3:Thrombolytic agentswill increase the risk of bleeding.
Rationale 4:Some antibiotics can diminish the antiplatelet actions of clopidogrel.
Rationale 5: Aspirin is an antiplatelet and can cause an increased risk of bleeding.
Global Rationale: Use with anticoagulants, other antiplatelet agents, thrombolytic agents, or NSAIDs, including aspirin and ibuprofen, will increase the risk of bleeding. Protein pump inhibitors, rifampin, or carbamazepine may increase the anticoagulant activity of clopidogrel.
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