Explain the relationship among chylomicrons, cholesterol, and the various forms of lipoproteins (LDL, HDL, etc.). What is the role of each one in the body? Why are some considered "bad" and others "good"? Where does each come from? Where could each end up?
What will be an ideal response?
Chylomicrons are complexes composed of triglycerides, cholesterol, and lipoprotein, assembled in the intestinal
epithelium. Most lipoprotein in blood is low-density, or LDL; other forms include very low-density (VLDL) and
high-density lipoprotein (HDL). The triglyceride portion of chylomicrons is a source of free fatty acids and
monoglycerides for cells, which use them for energy or convert them back to triglycerides for energy storage.
Cholesterol is a precursor for steroid hormones and bile components and, along with phospholipids synthesized
from fatty acids, a structural component of cell membranes. LDLs are a means of transporting cholesterol to most
cells, whereas HDLs transport cholesterol primarily to the liver. LDL is "bad" or "lethal" because elevated LDL is
associated with atherosclerosis. HDL is "good" or "healthy" because it takes cholesterol to the liver, where it is
metabolized or excreted.
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