Compare and contrast uncompensated and compensated respiratory acidosis
What will be an ideal response?
In uncompensated respiratory acidosis, CO2 levels are elevated but [HCO3-] remains normal. The result is a decrease in pH because, although the introduction of one CO2 into the ECF results in the formation of one H+ via the carbonic acid-bicarbonate equation, the normal [HCO3-] is 600,000 times greater than the [H+]; therefore, adding one CO2 to a solution ultimately has a significantly greater effect on [H+] than on [HCO3]. In compensated respiratory acidosis, compensatory measures act to restore pH to normal. These include chemical buffers, which take up additional H+, and the kidneys, which conserve and make new HCO3- while excreting more H+.
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