In vivo, the primary activator of the coagulation cascade occurs via the:
a. intrinsic pathway.
b. extrinsic pathway.
c. common pathway.
d. either intrinsic or extrinsic pathway.
B
The classic theory of coagulation is viewed as occurring through two distinct pathways, intrinsic and extrinsic, which share a common "final" pathway, formation of insoluble fibrin. It is now known that the classic cascade theory of coagulation illustrates what occurs in vitro. In vivo, the primary activator of the coagulation cascade occurs via the extrinsic pathway. The intrinsic pathway serves to amplify the coagulation cascade.
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