Salicylates primarily inhibit the synthesis of which substance?
1. Pyrogens
2. Superoxide radicals
3. Histamines
4. Prostaglandins
Correct Answer: 4
Rationale 1: Pyrogens are substances that increase body temperature. Salicylates do not act directly on the pyrogens.
Rationale 2: Superoxide radicals are blocked by ibuprofen.
Rationale 3: Histamines are an important chemical substance released during the inflammatory process and are not blocked by salicylates.
Rationale 4: Aspirin blocks the synthesis of prostaglandins by inhibiting the enzyme cyclooxygenase (COX).
Global Rationale: All NSAIDs act by inhibiting the synthesis of prostaglandins which are local hormones found in virtually every tissue. Prostaglandins have many diverse functions depending on their location. Pyrogens are substances that increase body temperature. Salicylates do not act directly on the pyrogens. Superoxide radicals are blocked by ibuprofen. Histamines are an important chemical substance released during the inflammatory process and are not blocked by salicylates.
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