A client is beginning aldesleukin (Proleukin) therapy for advanced renal carcinoma. The nurse should monitor the client for:
1. capillary leak syndrome.
2. hypertension.
3. hyperglycemia.
4. hyperuricemia.
Correct Answer: 1
Rationale 1: Capillary leak syndrome is a significant side effect of aldesleukin and can be fatal.
Rationale 2: Aldesleukin does not cause hypertension.
Rationale 3: Hyperglycemia is not a side effect of aldesleukin.
Rationale 4: Hyperuricemia is not a side effect of aldesleukin.
Global Rationale: Aldesleukin is a toxic drug that has the potential to cause serious adverse effects in virtually any organ system. Many of the adverse effects are caused by capillary leak syndrome, a serious condition in which plasma proteins and other substances leave the blood and enter the interstitial spaces because of porous capillaries. If not monitored carefully, capillary leak syndrome can result in death. The drug is not associated with hypertension, hyperglycemia, or hyperuricemia.
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