Histone deacetylase (HDAC) inhibitors are commonly used as mood stabilizers or in the treatment of neurodegenerative diseases. What effect would a HDAC inhibitor have on the target cells?
What will be an ideal response?
A histone deacetylase removes acetyl groups from the histone tails. This process results in tighter chromosome compaction and thus less transcription of the genes in that region of the chromosome. HDAC inhibitors block this enzyme, resulting in hyperacetylation of histones and an increase in gene expression in the target cells, which can increase transcription (and translation) of gene products that may be decreased in the diseased tissues.
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A genetic disorder characterized by impaired blood clotting is ____
a. leukemia b. sickle cell anemia c. hemophilia d. atherosclerosis e. hypertension
Using the analogy of a 12-hour geologic time clock
a. prokaryotes appear shortly after 5 a.m. b. eukaryotes appear at 9 a.m. c. dinosaurs appear at 10 a.m. d. early fishes appear at 11 a.m. e. the first humans appear at 11:59 a.m.
Which of the following has the highest blood pressure?
a. right ventricle b. right atrium c. aorta d. left atrium e. pulmonary circulation
The human X and Y chromosomes _____
A) are both present in every somatic cell of males and females B) are the same size and have the same number of genes C) include genes that determine an individual's sex D) are called autosomes