An older adult client presents with signs and symptoms related to digoxin toxicity. Which age-related change may have contributed to this problem?
a. Increased total body water
b. Decreased renal blood flow
c. Increased gastrointestinal motility
d. Decreased ratio of adipose tissue to lean body mass
B
Decreased renal blood flow and reduced glomerular filtration can result in slower medication excretion time, potentially leading to toxic drug accumulation. Aging results in decreased total body water and gastrointestinal motility and an increase in the ratio of adipose tissue to lean body mass, but is not related to digoxin toxicity.
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