What substance is known to inactivate cyclooxygenase, causing impairment of platelet function?
a. Aspirin
b. Calcium
c. Tylenol
d. Vitamin K
ANS: A
Aspirin inactivates the enzyme cyclooxygenase, blocking thromboxane A2 production and causing impairment of platelet function (called aspirin effect). Thromboxane A2 causes Ca+2 to be released and promotes platelet aggregation and vasoconstriction.
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