Meperidine (Demerol) is not recommended for children in sickle cell crisis because it:
a. may induce seizures.
b. is easily addictive.
c. is not adequate for pain relief.
d. is given by intramuscular injection.
ANS: A
A metabolite of meperidine, normeperidine, is a central nervous system stimulant that produces anxiety, tremors, myoclonus, and generalized seizures when it accumulates with repetitive dosing. Patients with sickle cell disease are particularly at risk for normeperidine-induced seizures. Meperidine is no more addictive than other narcotic agents. Meperidine is adequate for pain relief. It is available for IV infusion.
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