Why are sublingual and buccal medications rapidly absorbed?
a. Their action is localized to the mouth.
b. They are metabolized in the liver.
c. Blood flow is diminished in these sites.
d. These drugs pass directly into systemic circulation.
ANS: D
Sublingual medications are rapidly absorbed into systemic circulation because of the increased blood flow to these areas and avoid the "first pass" effect of the liver where extensive metabolism usually takes place. These routes do not contain drug effects to the oral area and they bypass the liver. These sites are highly vascular.
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