The nurse is preparing to administer medication to a patient receiving cyclophosphamide (Cytoxan). To protect against the side effect of hemorrhagic cystitis, the nurse would expect to administer which drug?
a. Decadron
b. Diphenhydramine (Benadryl)
c. Leucovorin
d. Mesna (Mesnex)
ANS: D
Cyclophosphamide can cause acute hemorrhagic cystitis; to prevent this, the nurse should expect to administer mesna, which is a protective agent. Decadron, diphenhydramine, and leucovorin are indicated for the prevention of side effects associated with different anticancer agents.
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