Which calcium channel blocker is easily titrated and beneficial in treating hypertension in patients with CAD or CVA?
a. Nifedipine (Procardia) c. Clevidipine (Cleviprex)
b. Nicardipine (Cardene) d. Diltiazem (Cardizem)
B
Nicardipine was the first available intravenous calcium channel blocker and as such could be more easily titrated to control blood pressure. Because this medication has vasodilatory effects on coronary and cerebral vessels, it has proven beneficial in treating hypertension in patients with coronary artery disease or ischemic stroke. Nifedipine is available only in an oral form, but in the past it was prescribed sublingually during hypertensive emergencies. Clevidipine is a new, short acting calcium channel blocker that allows for even more precise titration of blood pressure in the management of acute hypertension. Diltiazem (Cardizem) is from the benzothiazine group of calcium channel blockers. These medications dilate coronary arteries but have little effect on the peripheral vasculature. They are used in the treatment of angina, especially that which has a vasospastic component, and as antidysrhythmics in the treatment of supraventricular tachycardias.
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