A client is receiving an antiviral drug that is a substrate of the CYP3A4 enzyme system. When a drug that is an inhibitor of the 3A4 system is added to the client's regimen, the nurse should assess the client for which result?
1. Toxicity of the antiviral drug
2. No change in viral-related symptoms
3. A decrease in the antiviral drug side effects
4. An increase in viral load
Correct Answer: 1
Rationale 1: The drug inhibitor will interact with the antiviral drug and inhibit metabolism of it, resulting in accumulation of the drug with possible toxic effects.
Rationale 2: A change in viral-related symptoms could occur, since the level of antiviral drug is increased.
Rationale 3: An increase in side effects of the antiviral drug could occur, since more of the drug will remain in the bloodstream.
Rationale 4: Since the serum level of the antiviral drug will be elevated, the viral load might decrease, not increase.
Global Rationale: The drug inhibitor will interact with the antiviral drug and inhibit metabolism of it, resulting in accumulation of the drug with possible toxic effects. A change in viral-related symptoms could occur, since the level of antiviral drug is increased. An increase in side effects of the antiviral drug could occur, since more of the drug will remain in the bloodstream. Since the serum level of the antiviral drug will be elevated, the viral load might decrease, not increase.
You might also like to view...
Creatinine clearance tests require which of the following?
A) 24-hour collection of urine B) Urine creatinine level C) Serum creatinine level D) All of the above are correct.
Maintaining balance can become increasingly difficult as age increases. Which normal characteristic(s) of an older adult's musculoskeletal system potentially contribute(s) to this mobility problem?
a. Stability of joints b. Decrease in muscle bulk c. Limited range of motion d. Abnormal joint contours e. Decreased tissue regeneration f. Impaired glucose metabolism
A nurse is caring for a client with pin insertions in his left thigh. Which of the following actions should the nurse perform to prevent infection to the pin site?
A) Avoid removing crusted secretions. B) Avoid applying moisturizing ointment to pin sites. C) Teach the client to cleanse the pin sites. D) Cleanse the skin at the pin sites moving inward.
The nurse learns that a client practices Buddhism. Which question should the nurse include when assessing this client's nutritional practices?
a. "How often do you eat pork?" b. "How many days a week do you routinely fast?" c. "Do you abstain from food from noon to the next day?" d. "Do you prefer your meat cooked well-done or medium-well?"