A client with type 2 diabetes has been taking chlorpropamide (Diabinese), a first-generation sulfonylurea oral hypoglycemic agent, for many years with good effect. Recently, the client was started on a 6-month course of isoniazid for a positive PPD test. Which of the following statements is TRUE about taking isoniazid while receiving sulfonylureas?

Question

a. This client should be closely monitored for loss of diabetic control.
b. The client will have to switch to insulin until the course of isoniazid is completed.
c. The client will have to stop taking the sulfonylurea until the isoniazid course of therapy is completed.
d. The sulfonylurea is not known to interact with isoniazid.

Answer 1

a. This client should be closely monitored for loss of diabetic control.
FEEDBACK:
a. When isoniazid is administered or discontinued in clients receiving sulfonylureas, the client should be observed closely for loss of diabetic control.
b. The client can continue on the sulfonylurea. .
c. The client can continue on the sulfonylurea. .
d. Isoniazid may have an antagonistic action on the sulfonylurea, and a larger dose may be required. .