For the patient's new immune system to function effectively in bone marrow recipients, some HLA allotypes must be shared because _____. (Select all that apply.)
a. professional antigen-presenting cells are host-derived
b. professional antigen-presenting cells are donor-derived
c. otherwise an autoimmune disease would develop
d. newly generated T cells are positively selected on the recipient's thymic epithelium
e. if all HLA molecules were mismatched, acute rejection of the grafted cells would occur.
b, d
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