Two proteins, Rag-1 and Rag-2, catalyze VDJ recombination. Where would you expect these proteins to be expressed?
A. thyroid and parathyroid
B. bone marrow only
C. bone marrow and thymus
D. thyroid only
E. blood serum
Clarify Question
What is the key concept addressed by the question?
What type of thinking is required?
Gather Content
What do you already know about antibodies? What other information is related to the question?
Choose Answer
Given what you now know, what information is most likely to produce the correct answer?
Reflect on Process
Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
C. bone marrow and thymus
Clarify Question
What is the key concept addressed by the question?
· This question is asking about the location of antibody production.
What type of thinking is required?
· Apply level:
o You are being asked to take what you already know and use, or apply, it to the specifics of antibody production.
Gather Content
What do you already know about antibodies? What other information is related to the question?
· VDJ segments are components of antibodies.
· Antibodies are proteins that are produced by B cells.
· B cells are a subtype of lymphocytes.
Choose Answer
Given what you now know, what information is most likely to produce the correct answer?
· The thyroid and parathyroid do not play a role in the production of antibodies.
· The blood serum house antibodies, but does not play a role in their production.
· Cells that give rise to B cells are found in the bone marrow.
· Lymphocytes then migrate to the thymus and other sites to mature.
Reflect on Process
Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
· Apply level:
o Answering this question correctly depended on your ability to use antibody production in a new situation. If you got an incorrect answer, did you remember that VDJ segments are components of antibodies, or that antibodies are produced by B cells, which are a type of lymphocytes? Did you have trouble extending antibody production to determine the correct answer?
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