How does PTEN affect the balance between proapoptotic and antiapoptotic signals?
a) PTEN cuts a phosphate group off of PKB, which throws the balance in an antiapoptotic direction.
b) PTEN removes the phosphate group from the 3-position of PIP3, converting it to PI(4,5)P2, which cannot activate PKB (AKT) and thus throws the balance in an antiapoptotic direction.
c) PTEN removes the phosphate group from the 3-position of PIP3, converting it to PI(4,5)P2, which cannot activate PKB (AKT) and thus throws the balance in a proapoptotic direction.
d) PTEN cuts a phosphate group off of PKB, which throws the balance in a proapoptotic direction.
Ans: c) PTEN removes the phosphate group from the 3-position of PIP3, converting it to PI(4,5)P2, which cannot activate PKB (AKT) and thus throws the balance in a proapoptotic direction.
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