Explain how codon bias and GC content can be used to detect horizontal gene transfer within a genome

What will be an ideal response?


nswer: If an organism rarely uses a particular amino acid and one gene sequence has significantly more codons for the otherwise rare amino acid, this codon bias can be used to infer horizontal transfer of the gene. GC content may also be significantly different in a gene that has been transferred horizontally compared to the average GC content of the majority of the genome.

Biology & Microbiology

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