The nurse is reviewing the patient's medication prior to the medication pass and realizes that gemfibrozil (Lopid) and warfarin (Coumadin) are to be administered concomitantly. This finding concerns the nurse, who is aware that the _______ will be _______
a. level of gemfibrozil; increased
b. level of gemfibrozil; reduced
c. anticoagulant effects; increased
d. anticoagulant effects; reduced
ANS: C
Gemfibrozil displaces warfarin from the plasma albumin, thereby increasing anticoagulant effects. The level of gemfibrozil will not be increased or decreased.
The anticoagulation effects will not be reduced, because free-floating drug is present in the system; the dosage of warfarin may need to be reduced.
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