Explain how mature, naive B cells co-express IgM and IgD

What will be an ideal response?


Naive B cells express IgM and IgD simultaneously through a mechanism involving alternative ways of processing the RNA transcript before translation. A primary transcript containing leader (L), V, D, J, C?, and C? is produced first. This transcript contains two distinct polyadenylation signal sequences, one following the C? exons (pA1) and the other following the C? exons (pA2). Processing results in the removal of either C? or C? exons (plus introns) through alternative splicing. The resulting mRNAs, which encode either C? or C?, are polyadenylated at the pA1 or pA2 site, respectively.

Health & Biomechanics

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Health & Biomechanics

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What will be an ideal response?

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The term _____ is used to describe polymorphic antigens that vary between individuals of the same species

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Health & Biomechanics

The prefixes hemi- and semi- each mean "half."?

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Health & Biomechanics