A client has been diagnosed with bipolar disorder. A review of family history reveals five additional cases in the three-generation pedigree. The nurse would suspect polymorphism in which genes?

Question

Note: Credit will be given only if all correct choices and no incorrect choices are selected.
Standard Text: Select all that apply.
1. CLOCK
2. GSK-3
3. CRY1
4. CRY2
5. GABA

Answer 1

1,3,4
Rationale 1: Single nucleotide polymorphisms (SPNs) of the CLOCK gene are significantly associated with bipolar disorder.
Rationale 2: GSK-3 is a neurotransmitter.
Rationale 3: CRY1 may be associated with the major depression that occurs in bipolar disorder.
Rationale 4: CRY2 may be associated with the major depression that occurs in bipolar disorder.
Rationale 5: GABA is a neurotransmitter.