How do eukaryotic transcription factors exert their effects on transcription when their binding sites can be thousands of base pairs away from the promoter?

A. Regulatory proteins bind the sequences and then slide along the DNA until they reach an RNA polymerase bound to a promoter.
B. After binding to the site, the regulatory protein releases the DNA and is targeted to the polymerase via coactivator proteins.
C. Once bound to the site, the regulatory protein catalyzes the formation of an effector molecule that then travels to and binds the polymerase.
D. The DNA between the bound site and the polymerase-promoter complex loops out, increasing proximity.


D

Biology & Microbiology

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