In naive T cell recirculation, entry of the cells into peripheral lymph nodes occurs through which specialized vessel?
A. Efferent lymphatic
B. Thoracic duct
C. Central artery
D. High endothelial venule
E. Sinusoid
ANS: D. The high endothelial venule is a specialized vessel in the lymph node paracortex that expresses adhesion molecules that mediate the binding and transmigration of naive T cells into lymph node tissue. The efferent lymphatic is a route of exit of T cells from the lymph node. The thoracic duct is a major site of drainage of lymph back into the blood circulation. A central artery is a vessel in the spleen around which are T cell lymphoid aggregates (periarteriolar lymphoid sheath). Sinusoids are blood channels in the spleen lined by fenestrated endothelium and phagocytic cells.
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